What range is recommended for the initial PEEP setting in patients with no prior information?

The recommendation for the initial PEEP setting in patients with no prior information typically falls within the range of 2 to 6 cmH2O. This range is considered a safe starting point for a variety of patients because it provides a balance that can help improve oxygenation without significantly increasing the risk of overdistension of the alveoli or compromising hemodynamics.

Setting PEEP too low may not sufficiently recruit collapsed alveoli, which can affect gas exchange and oxygenation. Conversely, a PEEP that is set too high can lead to potential complications, such as reducing venous return or causing barotrauma in patients with compromised lung function. Thus, starting within this range allows for careful monitoring and adjustment based on the patient's response and clinical status.

It's also important to note that clinicians would generally titrate PEEP in conjunction with other ventilatory parameters and patient conditions for optimal outcomes.