What does a decrease in FEno indicate about airway inflammation?

A decrease in fractional exhaled nitric oxide (FEno) is indicative of a reduction in airway inflammation. FEno levels are a biomarker used to assess eosinophilic inflammation in the airways, which is commonly associated with conditions such as asthma. When there is less inflammation, the production of nitric oxide by the airway epithelial cells tends to decrease, thereby lowering the FEno levels.

In clinical practice, monitoring FEno can help therapists and physicians evaluate the effectiveness of anti-inflammatory treatments, such as inhaled corticosteroids. A decrease in FEno suggests that the inflammation is responding positively to these interventions, leading to improved airway function and reduced symptoms.

Understanding this concept is essential in the management of respiratory conditions, as it allows healthcare providers to track changes in inflammation and adjust treatment plans accordingly. The significance of a decrease in FEno emphasizes the importance of effective management of airway inflammation for improved patient outcomes.