In initial mechanical ventilation settings for infants, what is the recommended tidal volume (Vt) range?

The recommended tidal volume (Vt) range for infants during initial mechanical ventilation settings is 4 to 6 mL/kg. This volume is considered appropriate because it allows for adequate ventilation while minimizing the risk of potential lung injury due to overinflation or barotrauma.

In this range, the tidal volume can effectively facilitate gas exchange, ensure proper oxygenation, and avoid hypercapnia. It is especially important to start with a lower volume in infants, as their respiratory systems are more sensitive and vulnerable compared to adults. The goal is to ventilate effectively while respecting their physiological limits, given that their lung tissue is still developing.

Choosing a tidal volume outside this recommended range, such as lower than 4 mL/kg or higher than 6 mL/kg, may not provide sufficient ventilation or may increase the risk of adverse effects, respectively. Hence, the 4 to 6 mL/kg range strikes a balance between safety and efficacy in ventilatory support for infants.